The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

Children from influential families in politics and businesses attend the Hyakkaou Private Academy. There, the hierarchy of the students are classified by a series of games. Students that win the games are on the ruling side and the students who lose become slaves. One day, a mysterious girl, Yumeko Jabami (Minami Hamabe), is transferred to Hyakkaou Private Academy. She looks pure and pretty, but she is actually a compulsive gambler and seeks out the thrill of taking calculated risks.